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Approximately ninety percent of the Amerindian population died out following contact with the Europeans; most of this was due to infectious disease against which they had no defense. [1]
Since different genes likely provide different resistances to infectious disease, it may be that eliminating 90% of the pre-contact gene pool has significantly distorted the true genetic picture of Lehi's descendants. Studies of pre-Columbian human remains have not shown any extinct haplotypes—as one would expect given the small contribution made by a Lehite colony. Gene frequency, however, could well have been altered by such a dramatic die-off, suggesting that caution should be used in assuming that modern Amerindian populations are an identical match for pre-Columbian gene frequencies.
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